Chloride Cetylpyridinium sida daawaynta COVID-19

Tijaabadu waxay muujisay soo noqnoqoshada jeermis-dileyaasha ammonium-ka quaternary sida daawaynta fayrasyo ​​badan, oo ay ku jiraan coronaviruses: ficilladan waxay baabi'inayaan dahaarka dufanka leh ee daboolay fayrasyada sida SARS-CoV-2 oo ku tiirsan. Xeryaha ammonium-ka Quaternary ayaa si weyn loogu talinayaa inay dilaan fayrasyada waxaana jira in ka badan 350 alaab oo ku jira Liiska EPA Liiska N: Daawooyinka jeermis-diidka ah ee loo adeegsado SARS-CoV-2 (Qalabka Dheeraadka ah kiimikooyinka ku jira liiska EPA ayaa la soo sheegay oo> 140 ayaa daciifin kara fayraska dhowr daqiiqo gudahood (18).
Macluumaadkani wuxuu noo horseeday baadi-goobka weyn ee xeryahooda ammonium-ka quaternary oo leh dhaqdhaqaaq ka dhan ah coronaviruses iyo aqoonsiga suurtagalka ah ee kiimikooyinka hore loogu tijaabiyey rugta oo loo adeegsan karo daaweyn suuragal ah COVID-19. Mid ka mid ah jeermis -dileyaasha la tusay in uu waxyeello u geysan karo fayrasyada (Qalabka Dheeraadka ah) oo si weyn loogu isticmaalo alaabta daryeelka shaqsiyeed waa chloride cetylpyridinium. Xaruntan waxaa inta badan laga helaa dhaqidda afka waxayna ku liis garaysaa FDA sida Guud ahaan Loo Qaddariyo inay tahay Ammaan (GRAS) sida in sidoo kale loo isticmaalo wakiilka jeermis -dilaha ee hilibka iyo waxyaabaha digaagga (illaa 1%). Chloride Cetylpyridinium ayaa loo isticmaalay tijaabooyin caafimaad oo badan, oo ay ku jirto daawayn ka dhan ah caabuqyada neef -mareenka ee ansixinaya isticmaalkiisa fayruska fayraska. Cetylpyridinium waxay u badan tahay inay kor u qaaddo ka -hortagga fayraska iyadoo la burburinaayo capsid -ka iyo sidoo kale iyada oo la adeegsanayo ficilkeeda lysosomotropic, kaas oo, sida kor lagu soo sheegay, uu ku badan yahay xeryaha ammonium -ka quaternary. Tani waxay kicineysaa su'aasha ah in qaar ka mid ah dawooyinka lagu aqoonsaday waxqabadka ka-hortagga fayraska ee ka dhanka ah SARS-CoV-2 in vitro ay u dhaqmaan si la mid ah, taas oo ah inay burburin karaan fayraska fayraska iyo sidoo kale inay ku ururaan lysosome ama endosomes iyo ugu dambeyntii xannibaadda gelitaanka fayraska. Daraasado dheeraad ah oo la daabacay ayaa soo jeediyay in saameyntan lagu yarayn karo isticmaalka ka-hortaggayaasha Cathepsin-L. 

 Chloride Cetylpyridinium (CPC)

Quaternary ammonium xeryahooda oo leh waxqabad coronavirus la yaqaan

Molecule

Waxqabadka fayruska

Farsamo

FDA ayaa oggolaatay

Isticmaala

Chloride ammonium Murine coronavirus, cagaarshowga C, Lysosomotropic Haa Isticmaalka kala duwan oo ay ku jiraan dheef -shiid kiimikaad
Chloride Cetylpyridinium Hargabka, cagaarshowga B, dabaysha 1 Wuxuu bartilmaameedsadaa capsid waana lysosomotropic Haa, GRAS Maandooriye, afka lagu dhaqo, qufaca, alaabta daryeelka shaqsiga, wakiilada nadiifinta iwm.

Waqtiga dhejinta: Aug-03-2021