Cetylpyridinium chloride sida daawaynta COVID-19

Tijaabadu waxay muujisay soo noqnoqoshada sare ee jeermiska ammonium-ka quaternary sida daawaynta fayrasyo ​​badan, oo ay ku jiraan coronaviruses: kuwanu waxay u dhaqmaan iyagoo deminaya daahanka difaaca ee dufanka leh ee fayrasyada sida SARS-CoV-2 ku tiirsan.Xeryahooda ammonium-ka afar-geesoodka ah ayaa si weyn loogu talinayaa in la dilo fayrasyada waxaana jira in ka badan 350 badeecooyin ah oo ku jira Liiska EPA N: jeermis-dileyaasha loo isticmaalo ka hortagga SARS-CoV-2 (Waxyaabaha Dheeraadka ah. Isku-ururinta jeermiska jeermiska iyo waqtiyada xidhiidhka (oo la xidhiidha fayraska badan) qaar badan oo ka mid ah jeermiska Kiimikooyinka ku jira liiska EPA ayaa la soo sheegay oo > 140 waxay damin karaan fayraska dhowr daqiiqo gudahood (18).
Macluumaadkani waxa uu noo horseeday in aanu raadino afar-geesood oo ammonium ah oo leh hawlo ka dhan ah coronaviruses iyo aqoonsiga suurtogalka ah ee kiimikooyinka hore loogu tijaabiyey rugta caafimaadka oo loo isticmaali karo daawaynta suurtagalka ah ee COVID-19.Mid ka mid ah jeermis-dileyaasha lagu muujiyay inay wax u dhimaan fayrasyada (Qalabka Dheeraadka ah) oo si weyn loogu isticmaalo alaabta daryeelka shakhsi ahaaneed waa cetylpyridinium chloride.Xaruntan waxaa inta badan laga helaa dhaqamada afka oo ay ku taxay FDA sida Guud ahaan loo tixgeliyo Badbaado (GRAS) sida in sidoo kale loo isticmaalo sidii wakiilka ka hortagga jeermiska ee hilibka iyo alaabta digaaga (ilaa 1%).Cetylpyridinium chloride ayaa loo isticmaalay tijaabooyin badan oo caafimaad, oo ay ku jirto daawaynta ka dhanka ah caabuqyada neef-mareenka oo ansaxinaya isticmaalkeeda fayruska ka-hortagga.Cetylpyridinium waxay u badan tahay inay kor u qaaddo firfircoonida fayraska iyada oo burburinaysa capsid iyo sidoo kale iyada oo loo marayo ficilkeeda lysosomotropic, taas oo, sida kor looga hadlay, waxay caadi u tahay xeryahooda ammonium ee quaternary.Tani waxay dhalinaysaa su'aasha ah in qaar ka mid ah dawooyinka lagu aqoonsaday waxqabadyada ka hortagga fayraska ee ka dhanka ah SARS-CoV-2 in vitro ay u dhaqmaan si la mid ah, kuwaas oo laga yaabo inay burburiyaan fayraska capsid iyo sidoo kale inay ku ururaan lysosome ama endosomes oo ugu dambeyntii xannibaan gelitaanka fayraska.Daraasado dheeraad ah oo la daabacay ayaa soo jeediyay in saameyntan lagu yarayn karo isticmaalka Cathepsin-L inhibitors.

 Cetylpyridinium chloride (CPC)

Iskudhisyada ammonium ee afar-geesoodka ah oo leh hawlo coronavirus ah oo la yaqaan